Metabolism*and*homeostasis*of*faKy*acid*synthaseis transcriponally regulatedbyUpstream S1mulatory*Factors*(USF1*and*USF2)*and*sterol*regulatory*element*binding. Fatty acid synthesis. • The enzymes of fatty acid synthesis are packaged together in a complex called as fatty acid synthase (FAS). • The product of FAS action is palmitic acid. (). • Modifications of this primary FA leads to other longer (and shorter) FA and unsaturated FA. Fatty Acid Activation. Different synthatases: Short (C12) Very long (>C16) Elongation and Desaturation. C to Cn – Cn. Elongation occurs with enzymes on the cytosolic face of the ER membrane. This is done by . Fatty acid synthesis pathway pdfFatty acid synthesis. • The enzymes of fatty acid synthesis are packaged together in a complex called as fatty acid synthase (FAS). • The product of FAS action is palmitic acid. (). • Modifications of this primary FA leads to other longer (and shorter) FA and unsaturated FA. Fatty Acid Activation. Different synthatases: Short (C12) Very long (>C16) Elongation and Desaturation. C to Cn – Cn. Elongation occurs with enzymes on the cytosolic face of the ER membrane. This is done by . Fatty Acid Metabolism. • Other Fatty Acid Oxidation. 1. Long Chain Fatty Acids ( Carbons or Greater) are Oxidized in Beta Oxidation Reactions in Peroxisomes 2. Fatty Acids with Odd Numbers of Carbons and some Amino Acids are Oxidized in β-οxidation, Yielding Propionyl-CoA. 2) De novo fatty acid synthesis uses lactate derived primarily from glucose metabolism in muscle and red blood cells. b. Amino acid precursors (e.g., alanine, branched-chain amino acids) 1) De novo fatty acid synthesis from amino acids is especially important during times of excess protein intake. Metabolism*and*homeostasis*of*faKy*acid*synthaseis transcriponally regulatedbyUpstream S1mulatory*Factors*(USF1*and*USF2)*and*sterol*regulatory*element*binding.Fatty acid synthesis. • The enzymes of fatty acid synthesis are packaged together in a complex called as fatty acid synthase (FAS). • The product of FAS action is. Sources of NADPH for FA Synthesis FA Synthesis. The synthesis of palmitic acid requires 7. ATPs and 8 Elongation occurs with enzymes on the cytosolic. The processes of fatty acid biosynthesis are known to be The intermediates in fatty acid synthesis are . The pathway can be visualized as a cyclic process in. o Intracellular catabolism of fatty acids to produce energy . 5. Methyl group transfer. 6. About 12 known Bdependent enzymes. 7. Only 2 in mammals a. Reduced importance in humans. • Critical diseases of this pathway has not been reported because of this. • Variation in its activity between individuals may have. - if you are looking

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